Autologous blood products have created a growing interest for use in a number of orthopaedic therapies. The healing effects of plasma are supported by growth factors released by platelets. These growth factors induce a healing process wherever they are applied.
Features and Benefits
- Producing ACP (Autologous Conditioned Plasma) with the Arthrex ACP System can be performed within minutes. Typical platelet rich plasma (PRP) systems take up to 45 minutes to process the blood for application, thereby delaying treatment and increasing the cost of the procedure.
- The ACP System can be used in clinic or under sterile conditions in an OR setting. The unique double syringe design allows for convenient and safe handling, as the whole preparation process takes place in a closed system.
- The cost of the ACP System is more affordable than conventional PRP devices.
- The IRAP centrifuge can be converted to work with the ACP System.
Mechanism of Action
Outside the bloodstream, platelets become activated and release proliferative and morphogenic proteins. These growth factors are known to be relevant for healing in a variety of tissue types including bone, tendon, cartilage and skin.1 Their main actions are:
- Induce proliferation and differentiation of various cell types (e.g., stem cell, osteoblast, epidermal cells)
- Enhance/modulate production of collagen, proteoglycan and Tissue Inhibitor of Metallo Proteinases (TIMP)
- Stimulate angiogenesis
- Chemotaxis
These benefits seem to involve synergistic effects of growth factors.2,3,4
References:
- Richter W., Alternativen und Visionen zur Verbesserung der Knorpelregeneration, Trauma Berufskrankh., 2002, 4, 100-103
- Borzini and Mazzucco (2005) Borzini P and Mazzucco L: Tissue Regeneration and in Loco Administration of Platelet Derivates: Clinical Outcomes, Heterogeneous Products, and Heterogeneity of Effector Mechanisms; Transfusion, 2005, 45, 1759 -1767
- Edwards et al., Transforming Growth Factor Beta Modulates the Expression of Collagenase and Metalloproteinase Inhibitor, The EMBO Journal, 1987, 6, 7,1899-1904
- Lynch et al., Role of Platelet-derived Growth Factor in Wound Healing: Synergistic Effects with other Growth Factors, Proc. Natl. Acad. Sci. USA, 1987, 84, 7696-7700
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